We Take Our Science Seriously.

No Bogus. No BS.

Below you will find published scientific research covering Cannabidiol, Cognitive Behavioral Therapy, mindfulness, and nutrition, all of which were taken into account in designing the Dala Wellness program for joint health

Holistic mindfulness and CBT 

approach for management of chronic pain 

• From (Ontario Ministry of Health and Long-Term Care) policy to implementation: A retrospective look at a community-based patient-centered model of care for chronic pain

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• Two-Year Follow-up of a Randomized Clinical Trial of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care for Chronic Low Back Pain

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• The Effectiveness of Mindfulness-based Cognitive Therapy on Psychological Symptoms and Quality of Life in Systemic Lupus Erythematosus Patients: 
  A Randomized Controlled Trial

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• A tailored-guided internet-based cognitive-behavioral intervention for patients with rheumatoid arthritis as an adjunct to standard rheumatological care: results of a randomized controlled trial

Nutrition & Rheumatoid Arthritis

• The effect of individualized diet challenges consisting of allergenic foods on TNF-α and IL-1β levels in patients with rheumatoid arthritis

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• Managing Rheumatoid Arthritis with Dietary Interventions

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• Dietary Therapy in Patients With Inflammatory Arthritis.

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• Rheumatoid arthritis–celiac disease relationship: Joints get that gut feeling

Cannabidiol (CBD) & Arthritis

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

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• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

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• Involvement of the endocannabinoid system in osteoarthritis

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• The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

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• Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

Cannabidiol (CBD) & Fibromyalgia

•  Safety and Efficacy of Medical Cannabis in Fibromyalgia

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• Cannabis & fibromyalgia in Israel

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• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
   

• Cannabis use in patients with fibromyalgia
   

• Cannabinoids for fibromyalgia

Cannabidiol (CBD) & Inflammation

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

• The endocannabinoid system: an emerging key player in inflammation

• Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

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• Cannabinoids, endocannabinoids, and related analogs in inflammation
   

• Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
   

• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
   

• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
   

• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
   

• Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
   

• Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
   

• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
   

• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
   

• Cannabinoids in clinical practice

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• Pure THC-V inhibits nitrite production in murine peritoneal macrophages
   

• Cannabinoids, inflammation, and fibrosis
   

• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
   

• Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain
   

• Protective effect of CBD on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells
   

• Mechanisms of action of CBD in adoptively transferred experimental autoimmune encephalomyelitis

Cannabidiol (CBD) & Osteoporosis Bone Health

• CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts

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• Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies

• Cannabinoids and bone: Friend or foe?
   

• Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
   

• Cannabinoids and the skeleton: From marijuana to reversal of bone loss
   

• The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy
   

• The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption
   

• Endocannabinoids and the regulation of bone metabolism
   

• Cannabinoid receptors and the regulation of bone mass
   

• Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health
   

• Peripheral cannabinoid receptor, CB2, regulates bone mass
   

• Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
   

• Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis
   

• Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family

Cannabidiol (CBD) & Stress

• Endogenous cannabinoid signaling is essential for stress adaptation
   

• Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
   

• Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output
   

• Neuromodulators, stress and plasticity: a role for endocannabinoid signaling
   

• Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
   

• Endocannabinoids and stress
   

• Stress regulates endocannabinoid-CB1 receptor signaling
   

• Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus
   

• Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
   

• Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression
   

• Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
   

• The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
   

• Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid